Ethylhydrocupreine hydrochloride
CAS No. 3413-58-9
Ethylhydrocupreine hydrochloride ( Optochin hydrochloride )
Catalog No. M28297 CAS No. 3413-58-9
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
50MG | 45 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameEthylhydrocupreine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionEthylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae .
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DescriptionEthylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae . Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum , with an IC 50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors ( ggTas2r1 , ggTas2r2 and ggTas2r7 ) agonist.(In Vitro):The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied. (In Vivo):The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs .
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SynonymsOptochin hydrochloride
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PathwayGPCR/G Protein
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TargetAntibacterial
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number3413-58-9
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Formula Weight376.9
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Molecular FormulaC21H29ClN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC[C@@H](C[N@@]1CC2)[C@@H]2C[C@H]1[C@H](O)C3=CC=NC4=CC=C(OCC)C=C34.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bajpai V, et al. Rapid screening for the adulterants of Berberis aristata using direct analysis in real-time mass spectrometry and principal component analysis for discrimination. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(6):799-807.
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